Autoimmune diseases affect the body in many different ways and, in fact, the same autoimmune disease can affect different areas in different individuals and can have a different progression. For example lupus can affect the skin and joints in one individual while it may affect predominately the lung and kidneys in another. Some autoimmune problems are temporary and do not progress, some are permanent, some can be fatal, and, frustratingly most seem to wax and wane without cause. All this means that the diagnosis and treatment of autoimmune diseases is very challenging.